Measuring Fibrinolysis
نویسندگان
چکیده
Abstract Physiological fibrinolysis under normal conditions progresses slowly, in contrast to coagulation which is triggered rapidly stop bleeding and defend against microbial invasion. Methods detect abnormalities are less simple poorly standardized compared with common tests. Fibrinolysis can be accelerated by preparing euglobulin from plasma reduce endogenous inhibitors, or adding plasminogen activators plasma. However, these manipulations complicate interpretation of results diagnosis a “fibrinolysis deficit.” Many observational studies on antigen levels activator inhibitor 1 thrombin-activatable inhibitor, zymogen active enzyme have been published. conclusions mixed there clear problems harmonization results. Viscoelastic methods the advantage being rapid used as point-of-care They also work whole blood, allowing contribution platelets explored. no agreed protocols for applying viscoelastic acute care hyperfibrinolysis direct therapy. The emergence SARS-CoV-2 dangers associated coagulopathy provide new challenges. A finding hospitalized patients high D-dimer fibrin breakdown products, indicative ongoing fibrinolysis. Well-established testing standardization signal that we should cautious using such tests prognostic indicators target therapies.
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ژورنال
عنوان ژورنال: Hamostaseologie
سال: 2021
ISSN: ['0720-9355', '2567-5761']
DOI: https://doi.org/10.1055/a-1325-0268